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    ALG-1001: Turning off the machinery of angiogenesis

     

    Clearing the VEGF burden

    “Bevacizumab pretreatment helps clear the initial VEGF burden,” Dr. Boyer explained. “ALG-1001 turns off VEGF production, angiogenesis, and reduces inflammation. Adding 1 bevacizumab pre-treatment in the stage 2 study improved the BCVA achieved with 1.0 mg of ALG-1001 by about 40%, compared to the 1.0-mg dose of ALG-1001 without bevacizumab pre-treatment in the stage 1 study. In the two combination arms, no increased efficacy over monthly bevacizumab was seen.”

    Dr. Boyer believes that these results are promising. “An important consideration is that ALG-1001 might be efficacious for the 50% of the patients with DME who have not had an adequate respond to repeated anti-VEGF treatments alone,” he added.

     

    David Boyer, MD

    E: [email protected]

    This article is based on a presentation Dr. Boyer delivered at the 2017 American Society of Retina Specialists meeting. Dr. Boyer is a consultant to Allegro Ophthalmics and a member of the company’s Scientific Advisory Board. ALG-1001 currently is investigational and not approved by the FDA for use in the United States.

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