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    Does dexamethasone implant add benefit in ranibizumab patients?


    Cataract to visual acuity

    One important aspect of interpreting results in steroid studies is understanding the contribution of cataract to visual acuity. There was limited follow-up to assess cataract progression, but the authors hypothesized that cataracts could be the reason that more patients had a >10-letter vision loss in the combination group.

    The manuscript also mentioned that a subanalysis showed that pseudophakic eyes might have had increased vision in the combination cohort and that phakic eyes benefited more in the ranibizumab cohort.

    “This is a short-term, 6 months randomized clinical trial in DME, whereas most clinical trials in DME run for a 3-year period,” Dr. Bakri said. “Therefore, we do not know the cumulative effect that differences in CST between groups may have on visual acuity in the long-term. For now, the conclusion from this trial is that it did not meet its primary endpoint in terms of visual acuity at 6 months.”

    Sophie Bakri, MD

    e. [email protected]

    Lynda Charters
    Lynda Charters is a freelance medical writer.


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