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    Dye from açai fruit safe, effective for use during chromovitrectomy


    Study results

    The mean patient age was 68 years and 64% of patients were women; 92% of eyes were phakic.

    Analysis of the questionnaire results showed that dye was considered useful in all eyes. On the grading scale of 0 to 10, the mean scores for identification of the posterior hyaloid and ILM were, respectively, 8.88 and 7.84 when compared with the surgeons’ experience with triamcinolone and brilliant blue staining.

    “These findings demonstrated the intraoperative efficacy of this new purple dye,” Dr. Maia said.

    The baseline minimal macular hole diameter was a mean of 689 ± 397 μm, which likely resulted in the low closure rate of 68%. BCVA improved from 1.18 ± 0.47 to 0.84 ± 0.38 (p < 0.05) logarithm of the minimum angle of resolution.

    In addition, Dr. Maia reported that biomicroscopy showed no abnormalities except for one eye 7 days postoperatively that had cells in the anterior chamber that resolved at the 30-day examination.

    The baseline IOP was 17.5 ± 4 at baseline, 18 ± 5 at 1 week, 18.5 ± 7 at 30 days, and 17.3 ± 4 at 90 days (p > 0.05).

    A retinal detachment developed in one eye at the 30-day examination, and another eye underwent a secondary IOL implantation because of capsular dehiscence. Finally, cells were present temporarily in the anterior chamber.

    ERGs showed no difference between the baseline readings and those obtained 30 days postoperatively.

    “The preliminary results showed that the new dye based on anthocyanins from the açai fruit at a 25% concentration was safe and useful for identifying the hyaloid and ILM during vitreoretinal surgery in humans at the 3-month follow-up,” Dr. Maia concluded. “Long-term follow-up and additional studies are necessary. However, the initial results suggested that the açai fruit dye may be an alternative dye for use in chromovitrectomy in humans.”

    Dr. Maia, who holds a patent on the intraocular use of dye based on anthocyanins from the acai fruit (E. oleracea), reported his results at the 2017 meeting of the American Society of Retina Specialists in Boston.


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