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    Real-world outcomes with aflibercept better in treatment-naïve patients

    Large study also finds better outcomes with consistent dosing regimen

    The global burden of neovascular age-related macular degeneration (AMD) is expected to increase as the population ages, and (to date) the anti-vascular endothelial growth factor (VEGF) drugs are considered first-line treatment, based on the results from numerous pivotal studies. Those studies led to the approval of both aflibercept and ranibizumab (and pegaptanib, although that compound is rarely used as a first-line treatment these days).

    Evidence remains strong that this class of drug is both efficacious and safe across a wide range of neovascular AMD patients.

    What about real-world outcomes?

    Clinicians do not yet know if treat-and-extend, PRN, or some other dosing regimen is best. Conflicting reports suggest that when anti-VEGF therapy is stopped, the clinical aspects of the disease return sooner than anticipated, making a case for continual monthly dosing.

    Investigating the effectiveness of aflibercept (Eylea, Regeneron) in patients with wet AMD, (PERSEUS) is a prospective, observational, non-controlled, multicenter cohort study to describe follow-up and treatment patterns in routine practice in 942 patients with AMD (treatment-naïve or previously treated) across 66 clinics in Germany. “Previously treated” in this study meant patients who received any pre-treatment.
     

    Study background

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